Keyword: microfabrication
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Local actin polymerization on lipid membrane driven by surface nanotopography
Recent studies have shown that cells are able to sense small topographical features and to respond to them by locally assembling different types of actin-based structures (actin-patches, podosomes) on these textures. These structures influence the motility of the cells, adhering or not to the surface (Fig.1A, Left), and the localization of podosomes in macrophages. Cell…
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Uncovering molecular mechanisms of developmental tissue coordination with spatiotemporal temperature perturbations
Temperature impacts all biochemical reactions inside a cell. For developing multicellular organisms, temperature fluctuations pose challenges because morphogenetic events depend on both, spatially and temporally coordinated cellular decisions. Despite this, most multicellular systems show a surprising degree of robustness with respect to temperature changes within certain temperature limits. With climate change pushing organisms more and…