Keyword: image analysis
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Tracking of cancer cell-matrix interactions in a fully controllable 3D fiber system
The mechanical, geometrical and chemical properties of the 3D fibrous extracellular matrix play a key role in cancer initiation and progression, by controlling the movement and fate of tumor cells as well as surrounding fibroblasts, immune or endothelial cells. A strong emphasis has been put recently on the development of matrices with controllable fiber properties…
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Deciphering protein-induced invagination at sub-nanometric resolution by cryo-electron tomography
Cryo-electron microcopy is revolutionising our vision of proteins and the cell (Nobel Prize 2017). One approach, known as isolated particle analysis, makes it possible to build atomic models of purified and homogeneous. At the same time, cryo-tomography (cryo-ET) is being developed to obtain molecular models of more complex samples, in vitro reconstituted or within cells…