Skill: motivation
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Multicolor multifocus microscopy for multidimensional single molecule imaging
The ability to control the wavefront at the output of an imaging system allows to correct the imaging system optical aberration but also to impose a controlled deformation to encode specific information in the recorded images. Diffractive optical elements (DOE) provide an efficient mean to manipulate light. When placed in the back focal plane of…
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Structural characterisation of VAP-NPHFFAT complex bound to DNA origami scaffold by Cryo-EM
The internship is part of a larger project which concerns the definition of the 3D structure of proteins forming membrane contact sites, by Cryo Electron Microscopy (EM), in vitro. We are particularly interested in understanding the architecture of the complex formed by VAP-A and OSBP between the endoplasmic reticulum and the golgi, a key complex…