Keyword: single-particle tracking
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Single-molecule biophysics of membrane proteins & emergent functionality
Conformational changes and diffusion dynamics of membrane proteins are key in regulating fundamental cell physiology. Membrane proteins are involved in the transport of ions, drugs or molecules across the lipid bilayer using different sources of energy – during which they undergo specific conformations & spatial re-arrangement in membranes. We are interested in deciphering nanoscale conformations…
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Exploring Membrane Phase Separation Dynamics Modulated by Active Actin Networks
Animal cells continually reshape and reorganize their surfaces to facilitate growth and development. The cell surface is a thin (~ 10 nm), essentially two-dimensional complex fluid. Its basic structure is provided by a lipid membrane. Notably, this membrane can undergo phase transition, giving rise to nano-scaled lipid domains [1]. These lipid domains play a crucial…