Keyword: kidney-on-chip
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Mechanisms of renal cyst formation studied with biomimetic kidney-on-chips
Genetic renal kidney diseases lead to the development of numerous cysts in the renal tubules, ultimately leading to kidney failure. Despite extensive work on the genetics and cell biology of these diseases, the precise mechanism of cyst formation, resulting from localized dilatation of the renal tubules, remains imperfectly understood. Renal tubules have an extremely controlled…